Since 1996, the Murry lab has worked to understand the mechanisms that underlie cardiovascular disease and to develop new treatments. We have a longstanding interest in the biology of myocardial infarction (heart attacks), and in particular, how the heart heals after infarction. The lab has a major focus in stem cell biology and tissue engineering, where we seek to understand the molecular basis for cardiovascular differentiation, and to harness the potential of stem cells to repair the heart. Recently, our group has begun to use stem cell approaches to study genetically based cardiomyopathies. We are deriving induced pluripotent stem cells (iPSCs) from patients with cardiomyopathy, and using cell biology and tissue engineering for “disease in a dish” studies. The lab is working on translating preclinical research by pursuing scaled-up manufacturing processes and investigating electrophysiology and immunology to circumvent graft arrythmia and rejection.